Hair Loss DNA Test

Hair is a defining feature of every individual’s appearance, influenced by a combination of genetic and environmental factors. Characteristics such as hair color, texture (straight or curly), thickness, and overall quality are largely determined by one’s genetic makeup, while external factors—like nutrition, hormonal changes, and hair care practices—can also play a significant role in shaping how hair ultimately looks. Today, genetic testing (DNA analysis) enables the identification and genotyping of numerous genetic loci linked not only to these morphological traits but also to hair-related disorders, including various forms of alopecia.

Alopecia is a complex condition, often genetic and autoimmune in nature, characterized by partial or complete hair loss. It can affect both men and women of any age. As a genetic disorder, alopecia demonstrates high heritability, influencing not just the likelihood of its onset but also the type and severity of hair loss experienced. Recent scientific studies have uncovered associations with over 70 specific genes, and ongoing research suggests that many more genetic variants may be involved. This growing understanding opens the door for more personalized approaches to diagnosis, risk assessment, and treatment, based on each individual’s unique genetic profile.

A Very Important Test

Thanks to advancements in Molecular Biology, we now have the ability to identify specific genes and mutations that are involved not only in the development of alopecia, but also in determining various morphological characteristics of hair—such as thickness, type (straight, wavy, or curly), color, greying, and overall quality.

Modern DNA testing can analyze nearly 500 genetic loci associated with hair traits and disorders. From this analysis, a genetic penetrance score can be calculated, which estimates an individual’s predisposition to alopecia and other hair-related conditions. This score provides valuable insight into both the likelihood and potential severity of hair loss based on one’s genetic profile.

This level of comprehensive genetic analysis is made possible through microarray technology, a method that enables the simultaneous genotyping of hundreds of loci using a small sample of genetic material (typically saliva or a cheek swab). The results not only help in early diagnosis and personalized treatment planning but also allow for preventive strategies in individuals who are genetically predisposed to hair disorders.

How do genes affect hair growth

Genetic Testing for Androgenetic Alopecia

Androgenetic alopecia, commonly known as male- or female-pattern baldness, is a complex, polygenic, and partially autoimmune condition that can affect individuals of all genders and ages. With the use of modern gene-mapping technologies, researchers have identified five key genetic regions that are strongly associated with the risk of developing androgenetic alopecia. These regions, when analyzed together, can reveal an individual's genetic predisposition to hair thinning or loss—even before visible symptoms appear.

To perform the test, genetic material is collected from the individual—usually via a drop of blood using a painless collection method. The Baldness DNA Test examines these specific gene variants to determine the likelihood of developing androgenetic alopecia. Results from the Hair Loss DNA Test are typically available within 7 days of sample collection and can provide critical insights that help dermatologists or hair restoration specialists develop preventive or early-intervention strategies tailored to the individual's genetic risk.

Genetic Testing for Greying

Another important morphological trait of hair is color, particularly the onset of greying, which tends to increase with age. However, many young individuals—regardless of gender—also experience premature greying. While environmental stressors (such as chronic stress or nutritional deficiencies) may contribute, a significant genetic component is often involved.

Research has identified a key gene associated with greying: IRF4, and more specifically, the rs12203592 mutation. IRF4 plays a crucial role in melanin production, and mutations in this gene lead to reduced melanin synthesis, resulting in the early appearance of grey hair.

The test to detect this mutation is conducted using real-time PCR (Polymerase Chain Reaction) from a small, non-invasive sample of biological material—typically collected via a painless method onto a special transport card. This allows for efficient transfer and analysis of genetic material, making it easy to integrate into clinical or cosmetic consultations for individuals concerned about premature greying.

Genetic Testing for Beard Thickness

The beard is a defining male trait and has gained significant aesthetic importance in recent years, with full and dense beards being especially popular. But why do some men naturally grow thicker facial hair while others do not? The answer lies in genetics.

Scientific advances have made it possible to examine the EDAR gene, specifically the rs365060 variant, which plays a critical role in facial hair thickness and growth. This gene variant has been strongly associated with dense beard growth and is considered a notable marker of male morphological features. Interestingly, studies suggest that this genetic trait has undergone limited evolutionary pressure, yet it continues to significantly influence what many associate with masculinity and visual identity in men.

Detection of the EDAR variant is performed using Real-Time PCR, a fast and highly accurate method. The test is simple, minimally invasive, and requires only a single drop of blood, which is safely preserved in a special collection system for laboratory analysis.

Genetic Testing for Eyebrow Thickness

Eyebrows play a vital role in facial aesthetics for both men and women. Their thickness and shape can influence perceived expressions, symmetry, and overall attractiveness. While grooming trends can enhance their appearance, the natural density and contour of eyebrows are primarily determined by genetics.

The gene most closely associated with eyebrow thickness and shape is FOXL2, and particularly the rs112458845 polymorphism. This gene codes for a DNA-binding protein expressed in facial tissues, including those involved in eyebrow formation. Preliminary studies have also suggested a potential link between this gene and eyelid hair density, although this association requires further scientific validation.

Testing for this genetic variant is done via Real-Time PCR from a painless blood sample—just a drop—collected and preserved in specialized kits. The results can help guide personalized aesthetic planning, eyebrow restoration procedures, or even predictive grooming strategies based on one’s genetic predisposition.

Techniques and Methods in the Field of Molecular Biology

Nearly 500 distinct DNA regions are tested and analyzed using advanced molecular biology techniques. This comprehensive genetic analysis provides valuable insights into an individual’s predisposition to hair loss. By examining specific genetic markers, scientists can identify variations linked to alopecia and other hair-related traits. These findings help assess hereditary risk factors and guide personalized prevention or treatment strategies for hair disorders.

Hair Loss DNA Test