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Diffuse alopecia is marked by generalized thinning of the hair across the scalp, rather than the formation of distinct bald patches. It is more frequently observed in women than in men and can develop gradually or suddenly.
Although the visible reduction in hair volume can be distressing—often leading to emotional strain, reduced self-esteem, and social or professional discomfort—there is encouraging news: modern treatment options have proven highly effective. With proper diagnosis and a tailored treatment plan, it is possible to restore hair density, improve scalp health, and help patients regain their confidence and quality of life.
Autologous PRP (Platelet-Rich Plasma) hair mesotherapy with growth factors has shown promising results in the treatment of diffuse alopecia. It is now widely used as a standalone or complementary therapy alongside supportive or pharmaceutical treatments.
The procedure involves injecting concentrated growth factors derived from the patient’s own blood into the affected areas of the scalp to stimulate hair follicle activity and promote natural regrowth. Each session lasts about 30 to 45 minutes and is minimally invasive, requiring no local anaesthesia. Treatments are typically repeated monthly until satisfactory hair density is restored.
Topical minoxidil, in 2% or 5% solutions, applied twice daily, is effective in managing chronic diffuse alopecia, and has demonstrated notable results in both male and female androgenetic alopecia.
As one of the few clinically proven pharmacological treatments for hair thinning and loss, minoxidil has been used safely and effectively worldwide for over two decades. It helps to stimulate hair follicles, prolong the growth phase, and increase hair density, making it a trusted option in long-term hair restoration strategies.
Acute with sudden loss of hair
Subacute in which the hair is lost over several months
Chronic Diffuse Alopecia in which the phase of thinning is repeated and overall lasts more than 6 months
The hair growth cycle is composed of three distinct phases: anagen (growth phase), catagen (transitional phase), and telogen (resting phase). In a healthy scalp, approximately 95% of hairs are in the anagen phase, which can last for several years, while the catagen and telogen phases are much shorter, lasting only a few weeks to months.
Female hair loss often occurs when there is a premature shift from the anagen phase to the catagen and telogen phases, shortening the growth cycle and reducing overall hair density. In certain types of female hair loss, the anagen phase may last only a few months instead of years.
It is normal to shed 100–150 hairs per day, particularly during activities like washing or combing, and this does not necessarily indicate a pathological condition. However, if hair loss exceeds 150 hairs per day, it may be a sign of underlying hair loss disorders, and medical evaluation and treatment should be considered.e-shaped band of hair usually remains intact along the sides and back (occipital area) of the scalp.Complete baldness is uncommon, and the pattern of hair loss is key to diagnosis.
Telogen effluvium occurs when a large number of hairs prematurely and suddenly shift into the telogen phase—the resting and shedding stage of the hair cycle. Under normal conditions, hair remains in the anagen (growth) phase for several years before gradually transitioning. In telogen effluvium, however, this transition happens too early, before new hairs are ready to replace them, leading to diffuse hair shedding and noticeable thinning.
Severe hair shedding—affecting up to 90% of the scalp hair—can result from exposure to chemical or toxic agents, such as chemotherapy drugs or radiation therapy. This abrupt loss occurs because these agents disrupt the normal hair growth cycle, forcing hairs into the telogen phase or directly damaging the follicles. Fortunately, in most cases, hair regrowth begins once the exposure stops, and the follicles gradually resume normal function.
Mixed alopecia occurs when multiple factors contribute to hair loss, affecting hair follicles in different ways. In some follicles, the anagen (growth) phase ends prematurely, leading to early shedding. In others, hair growth ceases even while the follicle remains in the anagen phase, disrupting the natural cycle. This complex interaction results in combined patterns of hair thinning, often requiring a multifaceted treatment approach tailored to the underlying causes.
Diffuse alopecia is characterized by widespread thinning of hair across the scalp and may result from a wide variety of internal and external factors. These include:
In many cases, diffuse hair loss is reversible once the underlying cause is identified and addressed. Early diagnosis and treatment are key to restoring hair health.
Diffuse alopecia is often reversible, and with timely and targeted intervention, hair density can be restored. Treatment focuses on identifying and eliminating the cause, supporting healthy hair regrowth, and preventing progression to chronic or androgenetic alopecia.